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| Section: General Cell & Molecular Biology » Molecular Evolution |
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Content
⇒ Molecular Evolution
⇒ Early Beginnings
⇒ The RNA World
⇒ The DNA World
⇒ Phylogenetic Analysis
⇒ The Evolution of Eukaryotic Cells
Proteins evolve at different rates because of intrinsic factors (repair
mechanisms) and extrinsic factors (environmental mutagens). Highly
conserved proteins apparently have only been able to tolerate a few minor
changes, whereas some other proteins have been able to absorb many
mutations without loss of function. Mutations that occur outside a region
involved with normal function of the molecule may be tolerated as a selectively
neutral mutation. Over geological time, these neutral mutations
tend to accumulate within a geneological lineage. If it is assumed
that such neutral mutations accumulate at a fairly constant rate for a highly
conserved protein, it is possible to establish the branching pattern of a
phylogenetic tree (also called a cladogram or an evolutionary tree). |
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The principle of parsimony is commonly used to determine the
minimum number of genetic changes required to account for the amino
or nucleotide sequence differences between organisms sharing a common
ancestor. The evolutionary distances separating organisms in a phylogenetic
tree are usually expressed in units of nucleotide mutations or amino
acid substitutions along each arm of the tree between branch points (see
Figure 12-1).
Notes
Some evolution rates (point mutations per 100 million
years):
Triose phosphate isomerase = 3
Hemoglobin = 21
Nonfunctional pseudogenes = 400
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