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Section: Genetics » Regulation of Gene Expression » Mechanisms in Eukaryotes
 
 
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  Activation of transcription
 
     
 
Content
⇒ Regulation of Gene Expression 3. A Variety of Mechanisms in Eukaryotes
⇒ Regulation at Transcription Level
⇒ Activation of transcription
⇒ Britten-Davidson model for unit of transcription
⇒ Gene battery
⇒ Chromosomal proteins and gene expression
⇒ Repression of transcription 
⇒ Specific DNA sequences controlling transcription
⇒ Transgenic plants to study regulatory sequences
⇒ Modification of DNA sequences and their transcripts in gene expression
⇒ Alternative splicing of transcripts
⇒ Regulation at translation level
⇒ Activation and repression of translation
⇒ Masked mRNA in eggs of sea urchin and Xenopus
⇒ Regulation by gene re-arrangement
⇒ Expression of immunoglobulin genes
⇒ Yeast mating type switching
⇒ Trypanosome surface antigen (VSG) switching
⇒ Synthesis of mRNA in pieces in VSG genes in trypanosome
⇒ Regulation by reversible phosphorylation
⇒ Signal transduction and second messengers
⇒ Proteins and peptide hormones and gene expression
⇒ Steroid hormones and gene expression
⇒ Interferon stimulated gene expression (without a second messenger)
⇒ Cell surface receptors in cholesterol metabolism and drug production
⇒ Ubiquitin protein and regulation of heat shock genes
Activation of transcription
Activation of transcription as a means of regulation of gene expression has been studied during the last more than 20 years, using techniques, which have undergone a revolution through the development of recombinant DNA technology during 1980s. In a chronological order, initially (1969-73), these studies involved formulation of theoretical models based on the occurrence of large proportion of repetitive DNA in eukaryotes. Later (1973-75), chromatin reconstitution experiments demonstrated a positive control exercised by non-histone chromosomal proteins and still later (particularly in 1980s and 1990s), the role of transcription factors was examined in detail in large number of cases.

 
     






     
     
 
 
     
 
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