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Section: Genetics » Chemistry of the Gene » Synthesis, Modification and Repair of DNA
 
 
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  Models of DNA replication
 
     
 
Content
⇒ Chemistry of the Gene 2.  Synthesis, Modification and Repair of DNA
⇒ DNA replication: general features 
⇒ Semi-conservative DNA replication in E. coli
⇒ Semi-conservative replication of chromosomes in eukaryotes
⇒ Semi-discontinuous DNA replication
⇒ Unidirectional and bidirectional DNA replication
⇒ RNA primers in DNA replication
⇒ Regulation of DNA replication by anti-sense RNA primer
⇒ Prokaryotic DNA polymerases
⇒ Eukaryotic DNA polymerases
⇒ Replicons for DNA replication
⇒ DNA replication in prokaryotes 
⇒ Experimental approaches for the study of DNA replication
⇒ Initiation of DNA replication
⇒ Elongation of DNA chain
⇒ Replication fork movement
⇒ Termination of DNA replication
⇒ DNA replication in eukaryotes 
⇒ DNA replication and cell cycle
⇒ Replication origins and initiation of DNA replication (cis and trans-acting elements)
⇒ Comparison of initiation of DNA replication with transcription initiation
⇒ Different steps involved in eukaryotic DNA replication
⇒ Synthesis of telomeric DNA by telomerase
⇒ Models of DNA replication
⇒ Replication fork model
⇒ Rolling circle model of DNA replication
⇒ Mitochondrial DNA replication and D-loops
⇒ RNA directed DNA synthesis (reverse transcription)
⇒ DNA modification and DNA restriction
⇒ DNA repair
⇒ Excision repair systems in E. coli
⇒ An SOS repair system in E. coli
⇒ DNA repair and genetic diseases in humans


Models of DNA replication
Replication fork model
The most extensively utilized mechanism of DNA replication involves formation of replication forks, moving in one direction in unidirectional replication and in both directions in bidirectional replication. This method can apply to both linear as well as circular DNA molecules. Replication of circular double helical DNA through formation of replication forks moving in both directions (bidirectional replication) is shown is Figure 26.30.
  
Model for replication of circular double helical DNA, based on formation of double forks due to bidirectional DNA replication.
Fig. 26.30. Model for replication of circular double helical DNA, based on formation of double forks due to bidirectional DNA replication.

 
     






     
     
 
 
     
 
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